Concepts

What did the see-through brain interface actually do?

48AI analysisDocumented

An idea drawn from this archive’s research and journal, either the author’s own speculation or generated by AI, and labelled as such.

In January 2024 Psychology Today reported on a study from the University of California San Diego, published in Nature Nanotechnology, that built a brain interface you can see through. The electrodes are made of graphene, a sheet of carbon one atom thick, so the whole array is transparent. It was placed on the surface of a mouse brain, under the skull.

The array recorded electrical signals from the brain's surface. At the same time, a two-photon microscope shone its laser through the array and watched neurons up to 250 micrometres deep (a quarter of a millimetre) light up as they fired, using calcium imaging. The researchers then trained an artificial intelligence model on the two recordings together, so that it learned to predict the deeper activity from the surface signals alone. The authors report that it could predict both the average activity and the activity of single cells.

That is the real advance, and it is a general one. Once the model has learned the relationship, the microscope is no longer needed: the surface array alone gives an estimate of activity it cannot directly measure, so an animal can be observed for longer while it moves freely. This is how neural decoding works in general. A device records what it can reach, and a model, trained against something that could see more, fills in the rest.

The conditions matter as much as the result. The work was done in laboratory mice. Placing the array took surgery, and training the model needed a window in the skull and a laboratory microscope. The authors describe the next step as moving beyond mouse models, and present the work as a route to less invasive implants and treatments for neurological disorders. "Transparent" describes the material, which lets light through. It does not mean the animal, or anyone, becomes transparent to the device.

  • Nature Nanotechnology study from UC San Diego, reported by Psychology Today on 24 January 2024
  • Transparent graphene electrode array recorded surface signals while a two-photon microscope imaged calcium activity up to 250 micrometres deep
  • An AI model (a bidirectional LSTM network) trained on both recordings predicted deep activity, average and single-cell, from surface signals alone
  • Laboratory mice only; the array was surgically placed and training required a cranial window and a microscope

Open questions

  • How well a model trained on one animal carries over to another is not established by the article.
  • The study shows inference a quarter of a millimetre below the surface. It says nothing about deep brain structures or about recording from outside the skull.
  • Whether the approach works in people has not been tested.

Not independently verified

This concept reports one peer-reviewed animal study. It establishes no capability beyond what that study demonstrated.

Topics: Technology · Nanotechnology

Keep reading

34AI analysisDocumented

Did anyone try to build a way in without surgery?

Yes, openly, and the programme documents say so. DARPA's Next-Generation Nonsurgical Neurotechnology programme — N3 — set out, in its own words, to develop high-performance bi-directional brain-machine interfaces for able-bodied service members. Bi-directional means read and write. Able-bodied means the purpose was not restoring lost function; the stated applications were controlling unmanned vehicles and cyber-defence systems. Six teams were funded in 2019. The published performance targets were specific: sixteen independent channels, within sixteen cubic millimetres of neural tissue, at fifty milliseconds of latency, using light, acoustic or electromagnetic energy rather than implanted electrodes. One funded team, led by Battelle, took a route between surgery and none. Its project, BrainSTORMS, proposed injecting magnetoelectric nanoparticles, guiding them to a region of the brain, and reading from and writing to them through a helmet. That is the programme's clearest link to nanotechnology. It is still an injection, and it was a research proposal, not a system shown working in a person. The programme is now listed as complete and retained for reference. What this establishes is intent and investment, publicly recorded. It does not establish that the targets were met, and the targets themselves describe a person wearing equipment, not a person at a distance.

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50AI analysisDocumented

How small is nanotechnology, and what can it do today?

Nanotechnology works at roughly 1 to 100 nanometres. A nanometre is one billionth of a metre. A sheet of paper is about 100,000 nanometres thick. A ladder of sizes helps: - A sheet of graphene: one atom thick, a fraction of a nanometre. - A lipid nanoparticle in an mRNA vaccine: roughly 100 nanometres, about the size of a virus. - A neuron's cell body: thousands to tens of thousands of nanometres across. - A sheet of paper: about 100,000 nanometres. - A 2016 neural dust sensor: about 3 millimetres long, or 3,000,000 nanometres. The last line is the point most often missed. Most of what is called nanotechnology in brain research is a device of ordinary, visible size built from nanomaterials: graphene electrodes, nanowire mesh, a millimetre-scale sensor. The parts that are truly nanoscale are particles, and a particle on its own cannot compute, store or transmit anything. What nanoscale technology does today, on the record: - Carries medicines and genetic instructions into cells, as in mRNA vaccines and other approved nanomedicines. - Makes electrodes thinner, softer or transparent, as in transparent brain-computer interfaces and graphene arrays now being tested in people during surgery. - Converts energy sent from outside the body into a local effect, in laboratories and animals: magnetoelectric nanoparticles respond to a magnetic field, and in optogenetics upconversion nan

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01Author's observationPattern

What Does a Future with Consent Look Like?

In the author's speculation, the world's population could be experiencing telepathic communication that no one has consented to. It is not limited to words. It can reach any of the physical senses. - Verbal communication. It can be heard aloud on the neurotech bullhorn. - Inside the skull. With the ears held shut, it can still be experienced internally, through voice-to-skull (V2K) technology. - Phantom sensations. Something felt on or in the body that has no visible cause. - Augmented reality visuals. Images added to what a person sees (see The Diving Ecosystem, Capability 9). None of it has been consented to. Statements suggest that most of it is weapons development, carried out by certain organizations within a union of approximately 200 organizations that has been sold access to the population of the United States, and of other countries. That rests on statements alone and is unverified. On the record: the microwave auditory effect is documented in laboratory research: pulsed microwaves can be heard as clicks or buzzes that seem to come from inside the head. No published research shows it delivering speech to a person at a distance. The feeling of something crawling on the skin, and brief glimpses of things that are not there, have many known medical causes and are worth a doctor's assessment (see The Diving Ecosystem, Capability 9). From the author: "Wouldn't a mobile

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