In January 2024 Psychology Today reported on a study from the University of California San Diego, published in Nature Nanotechnology, that built a brain interface you can see through. The electrodes are made of graphene, a sheet of carbon one atom thick, so the whole array is transparent. It was placed on the surface of a mouse brain, under the skull.
The array recorded electrical signals from the brain's surface. At the same time, a two-photon microscope shone its laser through the array and watched neurons up to 250 micrometres deep (a quarter of a millimetre) light up as they fired, using calcium imaging. The researchers then trained an artificial intelligence model on the two recordings together, so that it learned to predict the deeper activity from the surface signals alone. The authors report that it could predict both the average activity and the activity of single cells.
That is the real advance, and it is a general one. Once the model has learned the relationship, the microscope is no longer needed: the surface array alone gives an estimate of activity it cannot directly measure, so an animal can be observed for longer while it moves freely. This is how neural decoding works in general. A device records what it can reach, and a model, trained against something that could see more, fills in the rest.
The conditions matter as much as the result. The work was done in laboratory mice. Placing the array took surgery, and training the model needed a window in the skull and a laboratory microscope. The authors describe the next step as moving beyond mouse models, and present the work as a route to less invasive implants and treatments for neurological disorders. "Transparent" describes the material, which lets light through. It does not mean the animal, or anyone, becomes transparent to the device.
- Nature Nanotechnology study from UC San Diego, reported by Psychology Today on 24 January 2024
- Transparent graphene electrode array recorded surface signals while a two-photon microscope imaged calcium activity up to 250 micrometres deep
- An AI model (a bidirectional LSTM network) trained on both recordings predicted deep activity, average and single-cell, from surface signals alone
- Laboratory mice only; the array was surgically placed and training required a cranial window and a microscope
Open questions
- How well a model trained on one animal carries over to another is not established by the article.
- The study shows inference a quarter of a millimetre below the surface. It says nothing about deep brain structures or about recording from outside the skull.
- Whether the approach works in people has not been tested.
References
- Transparent Brain-Computer Interface Uses AI and Nanotech — Psychology Today (2024)
- The study — Nature Nanotechnology (2024)
- Can a machine read what you are thinking?
- What would it actually take to do this without consent?
The article and the paper are cited for what the study did and the limits its authors stated.
Not independently verified
This concept reports one peer-reviewed animal study. It establishes no capability beyond what that study demonstrated.
Topics: Technology · Nanotechnology